Holins kill without warning
نویسندگان
چکیده
منابع مشابه
Bacteriophage holins: deadly diversity.
Bacteriophage biology has been the source of many of the fundamental paradigms of molecular genetics. The infective cycles of phages like l, T4, and T7 have been characterized in great detail; the precise sequence of gene expression and many of the decisive regulatory events are known. Indeed, the only developmental step in biology that is sufficiently well understood to be quantitatively model...
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متن کاملHolins: the protein clocks of bacteriophage infections.
Two proteins, an endolysin and a holin, are essential for host lysis by bacteriophage. Endolysin is the term for muralytic enzymes that degrade the cell wall; endolysins accumulate in the cytosol fully folded during the vegetative cycle. Holins are small membrane proteins that accumulate in the membrane until, at a specific time that is "programmed" into the holin gene, the membrane suddenly be...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2001
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.151247598